Results
| PMID | 19230876 |
| Gene Name | CCL2 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | MCP-1, MIF,LEP, and CA-125 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2010 May 1;93(7):2137-44. doi: 10.1016/j.fertnstert.2008.12.121. Seeber, Beata| Sammel, Mary D| Fan, Xuejun| Gerton, George L| Shaunik, Alka| Chittams, Jesse| Barnhart, Kurt T Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. OBJECTIVE: To identify potential novel biomarkers that differ between subjects with and without endometriosis and that might aid in developing a noninvasive, serum-based diagnostic test. DESIGN: Case-control evaluation of a diagnostic test. SETTING: University medical center. PATIENT(S): Consenting women of reproductive age undergoing laparoscopy for indications of pain, infertility, elective tubal ligation, tubal reanastomosis, or other benign indication. INTERVENTION(S): Diagnostic laparoscopy and peripheral venipuncture. MAIN OUTCOME MEASURE(S): Concentrations of low-molecular-weight proteins in serum; surgical staging of endometriosis. RESULT(S): Six proteins were found that were differentially expressed between those with and without disease and that had good diagnostic properties. Taken together in a two-step diagnostic algorithm, we were able to diagnose 55% of subjects, with 99% accuracy as to the status of disease. Further combining this algorithm with that derived by our previous study of serum putative markers (monocyte chemoattractant protein-1, migration inhibitory factor, leptin, and CA-125) improved our diagnostic capability to 73% of subjects, with 94% overall accuracy. CONCLUSION(S): This study is the critical first step in the identification of potential novel biomarkers of endometriosis. Future identification of the proteins and further validation in a second population is needed before applying these findings in clinical practice. Mesh Terms: Adolescent| Adult| Blood Proteins/*analysis/*metabolism| Case-Control Studies| Diagnostic Techniques, Obstetrical and Gynecological| Endometriosis/classification/diagnosis/*metabolism/pathology| Evaluation Studies as Topic| Female| Humans| Middle |
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